1.
Clin Toxicol (Phila)
; 59(1): 71-72, 2021 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-32538692
Assuntos
Acetaminofen/intoxicação , Acetilcisteína/uso terapêutico , Analgésicos não Narcóticos/intoxicação , Antídotos/uso terapêutico , Overdose de Drogas/tratamento farmacológico , Fomepizol/uso terapêutico , Adulto , Overdose de Drogas/sangue , Overdose de Drogas/diagnóstico , Quimioterapia Combinada , Feminino , Humanos , Pessoa de Meia-Idade , Resultado do Tratamento
2.
J Med Toxicol
; 4(2): 109-14, 2008 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18570172
RESUMO
Intravenous fat emulsions (IFE) are traditionally used as a component of parenteral nutrition therapy. Recently, IFE was used to resuscitate severe local anesthetic drug toxicity. This review focuses on the potential role of IFE in treatment of toxicity due to local anesthetics and other lipid-soluble drugs. The general properties of IFE, metabolic fate, and associated adverse events are described. Cases of local anesthetic toxicity treated with IFE are presented along with a discussion of the possible antidotal mechanisms. Initial investigations into the antidotal use of IFE for lipophilic central nervous and cardiovascular drug toxicity are also reviewed.